Druglikeness is a qualitative concept used in drug design for how \"druglike\" a substance is with respect to factors like bioavailability. It is estimated from the molecular structure before the substance is even synthesized and tested. The calculation of drug-like property can give us better assumption of biological activity of certain molecule. The theoretical calculation and maintains of certain properties of a molecule can fulfill the parameters which are essential to show certain biological activity. Druglike properties are characteristics of compounds, which need to be in balance to make compounds suitable to act as drugs. Druglikeness may be defined as a complex balance of various molecular properties and structural features which determine whether particular molecule is similar to the known drugs. These properties, mainly hydrophobicity, electronic distribution, hydrogen bonding characteristics, molecule size and flexibility and presence of various pharmacophoric features influence the behavior of molecule in a living organism, including bioavailability, transport properties, affinity to proteins, reactivity, toxicity, metabolic stability and many others.
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